Changes of hypothalamus-pituitary hormones in patients after total removal of craniopharyngiomas / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 357-360, 2004.
Article
Dans Anglais
| WPRIM
| ID: wpr-346670
ABSTRACT
<p><b>BACKGROUND</b>This paper aimed to elucidate the changes of hypothalamus-pituitary hormones in patients after total removal of craniopharyngiomas.</p><p><b>METHODS</b>A total of 40 patients with craniopharyngiomas received surgery. The levels of triiodothyronine (T3), thyroxine (T4), thyrotropic hormone (TSH), antidiuretic hormone (ADH), and adrenocorticotropin (ACTH) were measured in the 40 patients before surgery and one week after surgery respectively.</p><p><b>RESULTS</b>Twenty-eight patients (70%) had hypothyroidism before surgery, but 38 (95%) had hypothyroidism after surgery (P < 0.01). Twenty-three patients (57.5%) had diabetes insipidus (DI) before surgery and 38 (95%) had DI after surgery (P < 0.001). The pre- and post-operative levels of ADH were (2.49 +/- 0.30) pg/ml and (2.80 +/- 0.29) pg/ml respectively (P > 0.05), whereas those of ACTH were (23.97 +/- 2.69) pg/ml and (15.60 +/- 1.91) pg/ml respectively (P < 0.05).</p><p><b>CONCLUSIONS</b>Hormone deficits after total removal of craniopharyngioma appear to be the common complication of surgery. Hypothyroidism and diabetes insipidus are more frequent after surgery than before surgery. Thyroxine and glucocorticoids should be administered routinely after total removal of craniopharyngioma.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Hormones hypophysaires
/
Tumeurs de l'hypophyse
/
Complications postopératoires
/
Chirurgie générale
/
Hormones thyroïdiennes
/
Sécrétions corporelles
/
Craniopharyngiome
Limites du sujet:
Adolescent
/
Adulte
/
Enfant
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Chinese Medical Journal
Année:
2004
Type:
Article
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