Effects of tetramethylpyrazine on cardiac function and mortality rate in septic rats / 中国结合医学杂志
Chinese journal of integrative medicine
;
(12): 610-615, 2012.
Article
Dans Anglais
| WPRIM
| ID: wpr-347147
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of tetramethylpyrazine (TMP) on cardiac function and mortality rate in septic rats.</p><p><b>METHODS</b>Fifty male Sprague-Dawley rats were randomized into a sham-operation group (sham group, n=10), normal saline group (NS group, n=20), and TMP group (n=20). The rats in the NS and TMP groups underwent cecal ligation and puncture (CLP) to induce sepsis. Rats in the NS group were injected with NS (10 mL/kg) immediately after CLP and 6 h after CLP. Rats in the TMP group were injected with TMP (10 mg/kg) at the same time points. Twenty-four hours after modeling, the mortality rates were observed in each group. Cardiac function and serum concentration of tumor necrosis factor α (TNF-α) were also tested. The correlation between TNF-α and the ejection fraction (EF) was observed. Left ventricle specimens were reserved for histomorphologic study.</p><p><b>RESULTS</b>Compared with the sham group, the NS and TMP groups had decreased EF values and increased mortality rates and serum TNF-α levels (P <0.05). The TMP group had a comparatively lower mortality rate and TNF-α level and a higher EF value compared with the NS group (P <0.05). Histomorphology indicated that myocardial inflammation in the TMP group was mild compared with that in the NS group. There was a negative correlation between TNF-α level and EF value (r=-0.583,P=0.000).</p><p><b>CONCLUSION</b>TMP could reduce the mortality rate of septic rats and had certain protective effects on cardiac function.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pharmacologie
/
Pyrazines
/
Débit systolique
/
Sang
/
Imagerie diagnostique
/
Analyse de survie
/
Échographie
/
Facteur de nécrose tumorale alpha
/
Rat Sprague-Dawley
Type d'étude:
Etude diagnostique
/
Étude pronostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Chinese journal of integrative medicine
Année:
2012
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS