Preliminary study on gene expression profile of endometrial adenocarcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 464-467, 2003.
Article
Dans Chinois
| WPRIM
| ID: wpr-347401
ABSTRACT
<p><b>OBJECTIVE</b>To determine candidate genes of endometrial adenocarcinoma.</p><p><b>METHODS</b>To compare the gene expression profile in 2 endometrial adenocarcinoma tissues and 2 normal endometria by HGEC-40s GeneChip probe including 4096 genes array. Expression differences between normal and malignant tissue groups were measured by GenePixPro3.0 software.</p><p><b>RESULTS</b>350 genes with a ratio below 0.5 and above 2.0 showed discrimination between normal and malignant groups. Thirty three genes with ratio above 3 were up-regulated, forty-four genes with ratio below 0.3 were down-regulated.</p><p><b>CONCLUSION</b>The overexpression of oncogenes with their disturbed or constitutively activated signal transduction cascades alone or in combination with the mutation-induced silencing of tumor suppressor genes is associated with malignant transformation.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Adénocarcinome
/
Tumeurs de l'endomètre
/
Protein-Serine-Threonine Kinases
/
Protéines du cycle cellulaire
/
Protéines proto-oncogènes c-kit
/
Analyse de profil d'expression de gènes
/
Protéines liées au GPI
/
Aurora kinases
/
Génétique
/
Protéines membranaires
Limites du sujet:
Femelle
/
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Oncology
Année:
2003
Type:
Article
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