Lysophosphatidylglycerol inhibits formyl peptide receptor like-1-stimulated chemotactic migration and IL-1beta production from human phagocytes
Experimental & Molecular Medicine
;
: 584-591, 2009.
Article
Dans Anglais
| WPRIM
| ID: wpr-34741
ABSTRACT
In this study, we observed that lysophosphatidylglycerol (LPG) completely inhibited a formyl peptide receptor like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic migration in human phagocytes, such as neutrophils and monocytes. LPG also dramatically inhibited IL-1beta production by another FPRL1 agonist serum amyloid A (SAA) in human phagocytes. However, LPG itself induced intracellular calcium increase and superoxide anion production in human phagocytes. Keeping in mind that phagocytes migration and IL-1beta production by FPRL1 are important for the induction of inflammatory response, our data suggest that LPG can be regarded as a useful material for the modulation of inflammatory response induced by FPRL1 activation.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Peptides
/
Phagocytes
/
Protéine amyloïde A sérique
/
Lysophospholipides
/
Monocytes
/
Chimiotaxie des leucocytes
/
Récepteurs de la lipoxine
/
Récepteurs aux peptides formylés
/
Interleukine-1 bêta
/
Granulocytes neutrophiles
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Experimental & Molecular Medicine
Année:
2009
Type:
Article
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