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Alternation and significance of CD4(+)CD45RA(+) and CD4(+)CD45RO(+) T cells in peripheral blood of colorectal cancer patients / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 362-364, 2003.
Article de Zh | WPRIM | ID: wpr-347424
Bibliothèque responsable: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the alternation and significance of CD4(+)CD45RA(+) T cells and CD4(+)CD45RO(+) T cells in peripheral blood of colorectal cancer patients.</p><p><b>METHODS</b>The expression of CD4(+) T cells, CD4(+)CD45RA(+) T cells and CD4(+)CD45RO(+) T cells in peripheral blood of 60 colorectal cancer patients were detected with flow cytometry pre-operatively and 1, 3 months post-operatively, compared with those of 10 healthy persons.</p><p><b>RESULTS</b>CD4(+) T cells expression of colorectal cancer patients was the same as the healthy persons. The proportion of CD4(+)CD45RO(+) T cells of colorectal cancer patients was higher, which descended post-operatively, especially in Dukes A and B patients, while CD4(+)CD45RA(+) T cells showed the opposite findings.</p><p><b>CONCLUSION</b>CD4(+)CD45RA(+) T cells and CD4(+)CD45RO(+) T cells, playing an important immune effect in colorectal cancer patients, is closely related to stage and prognosis.</p>
Sujet(s)
Texte intégral: 1 Indice: WPRIM Sujet Principal: Anatomopathologie / Période postopératoire / Pronostic / Chirurgie générale / Sang / Tumeurs colorectales / Lymphocytes T CD4/ / Antigènes CD45 / Allergie et immunologie / Stadification tumorale Type d'étude: Prognostic_studies Limites du sujet: Adult / Aged / Female / Humans / Male langue: Zh Texte intégral: Chinese Journal of Oncology Année: 2003 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Anatomopathologie / Période postopératoire / Pronostic / Chirurgie générale / Sang / Tumeurs colorectales / Lymphocytes T CD4/ / Antigènes CD45 / Allergie et immunologie / Stadification tumorale Type d'étude: Prognostic_studies Limites du sujet: Adult / Aged / Female / Humans / Male langue: Zh Texte intégral: Chinese Journal of Oncology Année: 2003 Type: Article