Construction of tissue-engineering skin with carrier of active composite dermal matrix / 中华烧伤杂志
Chinese Journal of Burns
;
(6): 272-274, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-347603
ABSTRACT
<p><b>OBJECTIVE</b>To construct of tissue engineering skin including active composite dermal matrix.</p><p><b>METHODS</b>The human fibroblasts and bovine collagen with type I were inoculated on the surface of porcine acellular dermal matrix (PADM) for construction of active dermal substitute, then epidermal cells were inoculated on the dermal matrix for gas-liquid interface culture. The tissue-engineering skin was observed by histological examinations.</p><p><b>RESULTS</b>The structure of fibroblasts in collagen was intact, which was used to construct composite dermal matrix with PADM. The epithelial structure of tissue-engineering skin was similar to that of normal skin with good cell differentiation. Some phenomena were showed in epidermis basic layer, stratum spinosum, granular layer and stratum corneum, desmosomes.</p><p><b>CONCLUSION</b>Fibroblasts-Collagen-PADM can be an optimal dermal matrix for construction of tissue-engineering skin.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Peau
/
Suidae
/
Transplantation
/
Peau artificielle
/
Techniques de culture cellulaire
/
Derme
/
Biologie cellulaire
/
Collagène de type I
/
Ingénierie tissulaire
/
Épiderme
Limites du sujet:
Animaux
/
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Burns
Année:
2008
Type:
Article
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