Expression of focal adhesion kinase in cardiac myocytes of hypertrophic ventricle / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 677-680, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-347700
ABSTRACT
<p><b>OBJECTIVES</b>To investigate the role of focal adhesion kinase (FAK) in the pathogenesis of cardiac hypertrophy induced by hypertension.</p><p><b>METHODS</b>Using immunofluorescent labeling, confocal microscopy and Western blotting, the expression and subcellular localization of FAK in the cardiac myocytes of left ventricle were determined in 2, 6, 12, and 18 month-old rats with spontaneously hypertensive heart failure (SHHF) along with age-matched control Wistar-Kyoto (WKY) rats.</p><p><b>RESULTS</b>There was no significant difference of FAK expression between 2 month-old SHHF and WKY rats (50.5+/-6.9 vs. 49.8+/-5.0, n=6, P>0.05). In contrast with the control groups, the expression of FAK significantly increased in 6, 12 and 18 month-old SHHF rats (130.6+/-3.0 vs. 47.3+/-1.3, 144.7+/-5.4 vs. 46.4+/-3.1, 141.4+/-9.8 vs. 48.5+/-2.2, each groups n=6, P<0.05) with FAK protein primarily cumulated in the intercalated disks and nuclei.</p><p><b>CONCLUSIONS</b>FAK may play a role in the cell signaling transduction leading to cardiac hypertrophy, presumably through regulations of hypertrophic gene transcription and RNA processing.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Rats de lignée SHR
/
Rats de lignée WKY
/
Transduction du signal
/
Hypertrophie ventriculaire gauche
/
Microscopie confocale
/
Myocytes cardiaques
/
Focal adhesion kinase 1
/
Ventricules cardiaques
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Hypertension artérielle
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Chinese Journal of Pathology
Année:
2007
Type:
Article
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