Apoptosis of acute myeloid leukemic cells induced by human recombinant soluble tumor necrosis factor-related apoptosis inducing ligand (TRAIL) / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 766-769, 2004.
Article
Dans Chinois
| WPRIM
| ID: wpr-347866
ABSTRACT
In order to investigate the effect of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) on acute myeloid leukemic (AML) cells, BMMNC or PBMNC of 39 cases of AML (patient group) and 21 normal persons (control group) were isolated; the cytotoxic effects of TRAIL at various concentration on the cells were evaluated by MMT, apoptosis were detected by flow cytometry. The results showed that TRAIL of various concentration could kill AML cells in various degrees, but had no killing effect on normal cells. It is concluded that TRAIL can kill AML cells through inducing apoptosis, and TRAIL has a promising prospect in clinical use.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pharmacologie
/
Sang
/
Protéines recombinantes
/
Cellules cancéreuses en culture
/
Leucémie aigüe myéloïde
/
Survie cellulaire
/
Apoptose
/
Relation dose-effet des médicaments
/
Ligand TRAIL
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Experimental Hematology
Année:
2004
Type:
Article
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