Study on the changes of IL-3 and its receptor in mice with immune-mediated aplastic anemia / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 684-686, 2004.
Article
Dans Chinois
| WPRIM
| ID: wpr-347885
ABSTRACT
The aim of this study was to find new idea for clinical treatment of aplastic anemia. Immune-mediated aplastic anemia mice were developed, IL-3 in the supernatant with PHA stimulating splenic cells was detected by ELISA, semi-quantiting analysis of IL-3R was performed by point hybridization. The results showed that the IL-3 level in the supernatant with PHA stimulating splenic cells of immune-mediated aplastic anemia mice was higher than controls, difference between them was significant (P <0.001), while amount of IL-3 receptor by semi-quantiting analysis was lower than control significantly. In conclusion, the IL-3 receptor expression level is important for pathogenesis and treatment strategy of aplastic anemia.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Moelle osseuse
/
ARN messager
/
Récepteurs à l'interleukine-3
/
Interleukine-3
/
Allergie et immunologie
/
Génétique
/
Anémie aplasique
/
Souris de lignée BALB C
/
Souris de lignée DBA
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Journal of Experimental Hematology
Année:
2004
Type:
Article
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