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Correlation between ABO blood type gene and attention-deficit hyperactivity disorder in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 371-373, 2009.
Article Dans Chinois | WPRIM | ID: wpr-347912
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation between ABO blood type gene and attention-deficit hyperactivity disorder (ADHD) in children.</p><p><b>METHODS</b>ABO blood types were determined using glass sheet method in 96 children with ADHD and their parents. O gene was identified using polymerase chain reaction and restriction fragment length polymorphism in patients with A or B blood type. Haplotype-based haplotype relative risk (HHRR), transmission-disequilibrium test (TDT) and Chi-square test were used to examine the association between ABO gene and ADHD.</p><p><b>RESULTS</b>TDT results showed significant differences in the allele of ABO between the 96 children with ADHD and within-family controls (chi2=6.017, df=2, P< 0.05). Chi-square test results showed differences in the allele of A and B (chi2=3.289, df=1, P=0.07) as well as O and B (chi2=3.629, df=1, P=0.057 ) between ADHD children and within-family controls. The frequencies of O and A genes were higher than that of B gene in ADHD children.</p><p><b>CONCLUSIONS</b>There was correlation between ABO blood type gene and ADHD in children. The risk of ADHD is increased in the presence of alleles O and A, but the risk is reduced in the presence of allele B.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Trouble déficitaire de l&apos;attention avec hyperactivité / Sang / Système ABO de groupes sanguins / Haplotypes / Allèles / Génétique Type d'étude: Etude d'étiologie / Étude pronostique Limites du sujet: Adolescent / Enfant / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Contemporary Pediatrics Année: 2009 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Trouble déficitaire de l&apos;attention avec hyperactivité / Sang / Système ABO de groupes sanguins / Haplotypes / Allèles / Génétique Type d'étude: Etude d'étiologie / Étude pronostique Limites du sujet: Adolescent / Enfant / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Contemporary Pediatrics Année: 2009 Type: Article