Results of stage I and II tongue squamous cell carcinomas treated with different modalities / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 302-305, 2008.
Article
de Zh
| WPRIM
| ID: wpr-348107
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the results of stage I and II tongue squamous cell carcinomas treated with different treatment modalities.</p><p><b>METHODS</b>The clinical data of 103 patients with stage I and II primary tongue squamous cell carcinoma treated with surgery or radiotherapy alone or combined modality therapy were reviewed retrospectively. The treatment results were compared by Log-rank test, Kaplan-Meier and Chi square test among three groups: surgery alone (S), radiotherapy alone (R) and combined modality therapy (surgery plus preoperative or postoperative radiotherapy, R + S/S + R), and the prognostic factors were also analyzed using Cox regression models.</p><p><b>RESULTS</b>The overall 5-year survival rate (OS) was 82.4% for stage I and 80.0% for stage II disease (P = 0.361). The 5-year survival rates of S, R and R + S/S + R groups were 90.3%, 68.4%, and 84.0%, respectively (P = 0.104). The local recurrence rates of those three groups were 2.5%, 35.7% and 5.7%, respectively (P < 0.001). Occult lymph node metastasis rate was 23.8%, frequently metastasized to level II lymph nodes. The patients with poorly differentiated carcinoma were found to have the highest regional recurrence rate. Local and regional recurrence was revealed as an independent prognostic factor.</p><p><b>CONCLUSION</b>Surgery alone can achieve good treatment result for stage I and II tongue squamous cell carcinomas, and lymph node dissection of level I to IV in the neck is recommended.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Anatomopathologie
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Évidement ganglionnaire cervical
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Radiothérapie
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Tumeurs cutanées
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Chirurgie générale
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Tumeurs du cerveau
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Tumeurs de la langue
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Carcinome épidermoïde
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Modèles des risques proportionnels
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Taux de survie
Type d'étude:
Observational_studies
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Prognostic_studies
Limites du sujet:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Chinese Journal of Oncology
Année:
2008
Type:
Article