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Predicting factors of present hepatitis C virus infection among patients positive for the hepatitis C virus antibody
Clinical and Molecular Hepatology ; : 376-381, 2013.
Article Dans Anglais | WPRIM | ID: wpr-34828
ABSTRACT
BACKGROUND/

AIMS:

To identify the predicting factors of present hepatitis C virus (HCV) infection among patients with positivity for antibodies to HCV (anti-HCV).

METHODS:

We analyzed patients who showed positive enzyme immunoassay (EIA) results and performed an HCV RNA test as a confirmatory test at Kyung Hee University Hospital at Gangdong from June 2006 to July 2012. The features distinguishing the groups with positive and negative HCV RNA results were reviewed.

RESULTS:

In total, 490 patients were included. The results of the HCV RNA test were positive and negative in 228 and 262 patients, respectively. The index value of anti-HCV, mean age, platelet counts, total bilirubin, prothrombin time international normalized ratio, albumin and alanine transaminase (ALT) levels differed significantly between the two groups. On multivariable analysis, an index value of anti-HCV >10 [odds ratio (OR)=397.27, P40 IU/L (OR=3.64, P=0.001), and albumin <3.8 g/dL (OR=2.66, P=0.014) were related to present HCV infection.

CONCLUSIONS:

Although EIA is not a quantitative test, considering the anti-HCV titer with ALT and albumin levels may be helpful in predicting present of HCV infection.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Numération des plaquettes / Bilirubine / ARN viral / Sérumalbumine / Odds ratio / Valeur prédictive des tests / Techniques immunoenzymatiques / Hépatite C / Hepacivirus / Anticorps de l&apos;hépatite C Type d'étude: Etude d'étiologie / Étude pronostique Limites du sujet: Adulte / Adulte très âgé / Femelle / Humains / Mâle langue: Anglais Texte intégral: Clinical and Molecular Hepatology Année: 2013 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Numération des plaquettes / Bilirubine / ARN viral / Sérumalbumine / Odds ratio / Valeur prédictive des tests / Techniques immunoenzymatiques / Hépatite C / Hepacivirus / Anticorps de l&apos;hépatite C Type d'étude: Etude d'étiologie / Étude pronostique Limites du sujet: Adulte / Adulte très âgé / Femelle / Humains / Mâle langue: Anglais Texte intégral: Clinical and Molecular Hepatology Année: 2013 Type: Article