Microbial glycosylation of cardamonin by Mucor spinosus / 药学学报
Acta Pharmaceutica Sinica
;
(12): 733-737, 2011.
Article
Dans Anglais
| WPRIM
| ID: wpr-348892
ABSTRACT
Microbial transformation of cardamonin by Mucor spinosus (CGMCC 3.3450) in preparative scale resulted in the isolation of two new products. Their structures were elucidated unambiguously by ESI-MS, 1H NMR, 13C NMR and 2D NMR spectra analyses as 4-O-beta-D-glucopyranosyl-6-hydroxy-2-methoxychalcone (1, 4-GluC) and 6-O-beta-D-glucopyranosyl-4-hydroxy-2-methoxychalcone (2, 6-GluC), respectively. The time-course of biotransformation by M. spinosus showed that both 4-GluC and 6-GluC appeared on the 2nd day. The optimal biotransformation temperature was 28 degrees C, the optimal biotransformation time was 72 h and the optimal concentration for cardamonin was 40 mg x mL(-1). This is the first time for successful microbial glycosylation of cardamonin in present research.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Glycosylation
/
Biotransformation
/
Spectroscopie par résonance magnétique
/
Structure moléculaire
/
Chimie
/
Spectrométrie de masse ESI
/
Chalcones
/
Glucosides
/
Métabolisme
/
Mucor
langue:
Anglais
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2011
Type:
Article
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