Quality evaluation of artificial musk based on its inhibitory effect on cyclooxygenase-2 / 药学学报
Acta Pharmaceutica Sinica
;
(12): 438-442, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-348937
ABSTRACT
The inhibitory ratio (1%) of artificial musk on cyclooxygenase-2 (COX-2) was determined by enzyme immunoassay (EIA). The dose-effect relationship between concentrations of artificial musk and 1% was established. It was found that artificial musk had obvious inhibitory action on COX-2. The concentration for 50% of maximum inhibitory effect (IC50) was about 2.26 mg x mL(-1). There was a good relationship between the logarithm concentrations of artificial musk and 1% when the concentrations of artificial musk ranged from 0.31-20.0 mg x mL(-1). The results indicated that this EIA method could be applied to evaluate the anti-inflammatory activity of artificial musk quickly, conveniently, sensitively and exactly. This paper provided a novel method and foundational research for the bioassay of artificial musk.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Acides gras monoinsaturés
/
Techniques immunoenzymatiques
/
Concentration inhibitrice 50
/
Relation quantitative structure-activité
/
Cyclooxygenase 2
/
Inhibiteurs de la cyclooxygénase 2
/
Métabolisme
/
Méthodes
/
Anti-inflammatoires
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2011
Type:
Article
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