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Quality evaluation of artificial musk based on its inhibitory effect on cyclooxygenase-2 / 药学学报
Acta Pharmaceutica Sinica ; (12): 438-442, 2011.
Article Dans Chinois | WPRIM | ID: wpr-348937
ABSTRACT
The inhibitory ratio (1%) of artificial musk on cyclooxygenase-2 (COX-2) was determined by enzyme immunoassay (EIA). The dose-effect relationship between concentrations of artificial musk and 1% was established. It was found that artificial musk had obvious inhibitory action on COX-2. The concentration for 50% of maximum inhibitory effect (IC50) was about 2.26 mg x mL(-1). There was a good relationship between the logarithm concentrations of artificial musk and 1% when the concentrations of artificial musk ranged from 0.31-20.0 mg x mL(-1). The results indicated that this EIA method could be applied to evaluate the anti-inflammatory activity of artificial musk quickly, conveniently, sensitively and exactly. This paper provided a novel method and foundational research for the bioassay of artificial musk.
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pharmacologie / Acides gras monoinsaturés / Techniques immunoenzymatiques / Concentration inhibitrice 50 / Relation quantitative structure-activité / Cyclooxygenase 2 / Inhibiteurs de la cyclooxygénase 2 / Métabolisme / Méthodes / Anti-inflammatoires langue: Chinois Texte intégral: Acta Pharmaceutica Sinica Année: 2011 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pharmacologie / Acides gras monoinsaturés / Techniques immunoenzymatiques / Concentration inhibitrice 50 / Relation quantitative structure-activité / Cyclooxygenase 2 / Inhibiteurs de la cyclooxygénase 2 / Métabolisme / Méthodes / Anti-inflammatoires langue: Chinois Texte intégral: Acta Pharmaceutica Sinica Année: 2011 Type: Article