Synthesis of ferulic acid derivatives and their inhibitory effect on platelet aggregation / 药学学报
Acta Pharmaceutica Sinica
;
(12): 305-310, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-348960
ABSTRACT
Ferulic acid, an useful compound of Chinese traditional medicine, was used as leading compound. Six ferulic acid derivatives were designed and synthesized based on bioisosterism. Their structures were characterized by IR, 1H NMR, 13C NMR and mass spectra. In vivo experiment showed that ferulic acid derivatives had good inhibitory effects on adenosine diphosphate (ADP) induced platelet aggregation, which were significantly higher than that of Ozagrel.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Relation structure-activité
/
Antiagrégants plaquettaires
/
Répartition aléatoire
/
Chimie
/
Agrégation plaquettaire
/
Acides coumariques
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2011
Type:
Article
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