Existing problems and strategies in liposome-mediated nucleic acid delivery / 药学学报
Acta Pharmaceutica Sinica
;
(12): 261-268, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-348967
ABSTRACT
Liposome-mediated nucleic acid delivery has been a focus recently, but in the course of delivering nucleic acid, some hurdles seriously limit the nucleic acid exerting treatment effect. This review refers to a series of problems such as low blood stability, reticuloendothelial system absorption, the lower targeting of liposome and the restriction of endosomal escape which are suffered in liposome-mediated nucleic acid delivery; and gives a detail introduction of strategies such as PEGylation, ligand modification, photochemical internalization, the application of degradation liposome and membrane-lytic peptide, to overcome those problems.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polyéthylène glycols
/
Polymères
/
Système phagocytaire mononucléé
/
Pharmacocinétique
/
Acides nucléiques
/
Chimie
/
Nanoparticules
/
Processus photochimiques
/
Liposomes
/
Métabolisme
Limites du sujet:
Animaux
/
Humains
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2011
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS