P53 abnormality and clinical prognosis of leukemia patients with complex chromosomal abnormalities / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 81-85, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-349033
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the p53 deletion in leukemia patients with complex chromosomal abnormalities (CCA) and the clinical significance.</p><p><b>METHODS</b>The p53 deletion status of 38 leukemia cases with CCA and 24 cases without CCA were analyzed by interphase fluorescence in situ hybridization (I-FISH).</p><p><b>RESULTS</b>The frequency of p53 deletion in the 38 patients with CCA (44.74%) was significantly higher than that in the 24 cases without CCA (4.16%) (P<0.01). The rate of complete remission in 13 cases of acute leukemia with CCA was 15.4%, with median survival time (MST) of 105 days.</p><p><b>CONCLUSION</b>I-FISH is a rapid, accurate and sensitive technique for detection of p53 deletion, patients with CCA have a higher p53 deletion and a lower complete remission rate and MST.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pronostic
/
Cellules de la moelle osseuse
/
Leucémies
/
Analyse de survie
/
Cellules cultivées
/
Mortalité
/
Protéine p53 suppresseur de tumeur
/
Aberrations des chromosomes
/
Hybridation fluorescente in situ
/
Délétion de gène
Type d'étude:
Etude diagnostique
/
Étude pronostique
Limites du sujet:
Adolescent
/
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2010
Type:
Article
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