Association of serotonin and norepinephrine transporter gene polymorphisms with the susceptibility to depression / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 388-392, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-349069
ABSTRACT
<p><b>OBJECTIVE</b>To determine whether the serotonin transporter (5-HTT) and norepinephrine transporter (NET) gene polymorphisms were associated with the susceptibility to depression.</p><p><b>METHODS</b>Five hundred and seventy-nine patients with depression, evaluated using a 17-item Hamilton Depression Rating Scale for Depression (HAMD), and 437 healthy controls, all of Chinese Han origin, were genotyped by polymerase chain reaction.</p><p><b>RESULTS</b>Both genotype distributions (P=0.033) and allele frequencies (P=0.023, OR = 1.250, 95% CI = 1.031-1.517) of NET-T182C were significantly different between patients and controls, where the T allele was associated with the onset of depression. Both NET-T182C T- and 5- HTTLPR L-carriers had higher baseline HAMD scores (P=0.032 and 0.023, respectively). There was an interaction between NET-T182C and 5-HTTLPR, where the combined genotype distributions were associated with both onset of depression (P=0.006) and the baseline HAMD scores (P=0.007).</p><p><b>CONCLUSION</b>This study suggested a positive relationship between the NET-T182C polymorphism and the susceptibility to depression, and a positive relationship between NET-T182C/5-HTTLPR polymorphisms and the severity of depression.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polymorphisme génétique
/
Études cas-témoins
/
Dépression
/
Prédisposition aux maladies
/
Transporteurs de la norépinéphrine
/
Transporteurs de la sérotonine
/
Études d'associations génétiques
/
Génétique
Type d'étude:
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2009
Type:
Article
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