Expression of cyclin G1 in laryngeal squamous cell carcinoma and its clinicopathologic significance / 中华病理学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the expression of cyclin G1 and its relationship with clinical pathological characters, p53 expression and microvessel density (MVD) in laryngeal squamous cell carcinoma (LSCC), and to investigate the prognostic value of cyclin G1 in LSCC.</p><p><b>METHODS</b>Using immunohistochemistry, 81 cases of LSCC were evaluated for cyclin G1 and p52 expression, MVD was assessed by CD34 staining. In 20 cases, similar assessment was made in the adjacent normal mucosa.</p><p><b>RESULTS</b>Compared to the normal laryngeal mucosa, the expressions of cyclin Gl, p53 and MVD were higher in LSCC than that in normal tissues. The positive rates of cyclin G1 and p53 expressions in LSCC were 61.7% (50/81) and 65.4% (53/81), respectively. The positive rates of cyclin G1 in LSCC with or without p53 expression were 71.7% (38/53) and 42.9% (12/28), respectively. The expression of cyclin G1 was significantly correlated with p53 (P = 0.011). The mean value of MVD was (51.23 +/- 16.46 mv) in cyclin G1 positive group, and(30.74 +/- 12.29 mv) in the negative group, and the difference was significant (P = 0.005). Furthermore, the over-expression of cyclin G1 was related to the histological grade, cervical lymph node metastases and 5 year survival (P = 0.002, 0.013 and 0.032 respectively).</p><p><b>CONCLUSIONS</b>Cyclin G1 is highly expressed in laryngeal squamous cell carcinoma, and is associated with the expression of p53 protein and tumor angiogenesis. It may play an important role in carcinogenesis and metastasis in LSCC, and may be one of prognostic indices for LSCC patients.</p>