Functional analysis of the single nucleotide polymorphisms in the PRKCZ gene / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 471-473, 2002.
Article
Dans Chinois
| WPRIM
| ID: wpr-350082
ABSTRACT
<p><b>OBJECTIVE</b>To study the function of 5 single nucleotide polymorphisms (SNPs) of the PRKCZ gene, a susceptibility gene for type 2 diabetes in Han population of North China, in the pathogenesis of the disease.</p><p><b>METHODS</b>Bioinformatic methods and reporter gene activity determination were used to analyze the function of the 5 SNPs.</p><p><b>RESULTS</b>The reporter gene activities of different alleles of 2 SNPs, rs427811 and rs809912, were obviously different, which implies that these 2 SNPs might be susceptibility loci of the disease.</p><p><b>CONCLUSION</b>The PRKCZ gene is further confirmed to be a susceptibility gene for type 2 diabetes in Han population of North China. Two SNPs in the gene play a role in the pathogenesis of the disease by affecting the expression level of PRKCZ gene.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Protéine kinase C
/
Ethnies
/
Prédisposition génétique à une maladie
/
Polymorphisme de nucléotide simple
/
Asiatiques
/
Diabète de type 2
/
Allèles
/
Protein kinase C-delta
/
Génétique
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Acta Academiae Medicinae Sinicae
Année:
2002
Type:
Article
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