Study of the gene expression pattern in the Kkay mouse with type 2 diabetes by genomic-scale gene expression analysis / 中国医学科学院学报

ABSTRACT

<p><b>OBJECTIVE</b>To study the genes differentially expressed in the liver of Kkay diabetic and normal mice by genomic-scale gene expression analysis.</p><p><b>METHODS</b>cDNA microarray chips containing 8,192 cDNAs were used to explore the gene expression pattern of Kkay mouse liver.</p><p><b>RESULTS</b>One hundred and fifty-four genes were screened out, including 68 complete cDNAs and expressed sequence tags, and among them 40 genes were up-regulated and 114 genes were down-regulated respectively.</p><p><b>CONCLUSION</b>Most of the gene expression analysis results were consistent with previous study, and the gene expression pattern of Kkay mouse based on cDNA microarray could be used for high-throughout screening out the genes associated with type 2 diabetes.</p>