Insulin neuroprotection and the mechanisms / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 976-981, 2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-350369
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the mechanism of neuroprotection of insulin and which blood glucose range was benefit for insulin exerting neuroprotective action.</p><p><b>DATA SOURCES</b>The study is based on the data from PubMed.</p><p><b>STUDY SELECTION</b>Articles were selected with the search terms "insulin", "blood glucose", "neuroprotection", "brain", "glycogen", "cerebral ischemia", "neuronal necrosis", "glutamate", "γ-aminobutyric acid".</p><p><b>RESULTS</b>Insulin has neuroprotection. The mechanisms include the regulation of neurotransmitter, promoting glycogen synthesis, and inhibition of neuronal necrosis and apoptosis. Insulin could play its role in neuroprotection by avoiding hypoglycemia and hyperglycemia.</p><p><b>CONCLUSIONS</b>Intermittent and long-term infusion insulin may be a benefit for patients with ischemic brain damage at blood glucose 6-9 mmol/L.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Glycémie
/
Encéphalopathie ischémique
/
Neuroprotecteurs
/
Utilisations thérapeutiques
/
Hyperglycémie
/
Insuline
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Chinese Medical Journal
Année:
2015
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS