Determination of thiodiglycolic acid in urine with gas chromatography-mass spectrometer / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 474-476, 2015.
Article
Dans Chinois
| WPRIM
| ID: wpr-350567
ABSTRACT
<p><b>OBJECTIVE</b>To establish a rapid determination method with gas chromatography-mass spectrometer (GC-MS) for thiodiglycolic acid (TDGA), a vinyl chloride (VCM) biomarker.</p><p><b>METHODS</b>A high- sensitivity determination method was established using a moderate methyl esterification instead of methyl esterification of highly toxic diazo reaction.</p><p><b>RESULTS</b>The standard curve regression linear equation of the method was y=8460.5x-4758.2, the linear coefficient was 0.999 7, the minimum quantity concentration was 2.0 µg/L, the range of precision value was 0.81%-2.38%, and the average recovery of standard addition was 99.0%-102.9%.</p><p><b>CONCLUSION</b>This method reduces the risk of traditional methyl esterification, improves the determination sensitivity compared with the GC-FPD method, and meets the determination requirement of TDGA.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Thioglycolates
/
Urine
/
Chloro-éthylène
/
Chromatographie gazeuse-spectrométrie de masse
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Année:
2015
Type:
Article
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