A novel trichostatin analogue culture of Streptomyces sp. CPCC 203909 / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1751-1754, 2015.
Article
Dans Chinois
| WPRIM
| ID: wpr-351271
ABSTRACT
By using a cell-based high throughput screening model for the CLA-1 up-regulator, Streptomyces 203909 was found to produce up-regulator of CLA-1. A novel trichostatin analogue was isolated from the rice fermentation of Streptomyces sp. CPCC 203909by a combination of various chromatographic techniques including column chromatography (CC) over silica gel, flash C18 CC, and reversed-phase HPLC. Its structure was identified as (-)-(R,2E,4Z)-7-[(4'-dimethylamino) phenyl]-4,6-dimethyl-7-oxohepta-2,4-dienoyl-L-glutamine (1) by the spectroscopic and chemical methods, and combination with the CD spectroscopy and Marfey's method. In the prelimi- nary assays, Compound 1 showed cytotoxicity against human embryonic kidney 293 cell line with IC50 value 35.3 [µmol · L(-1).
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Streptomyces
/
Structure moléculaire
/
Survie cellulaire
/
Chimie
/
Cellules HepG2
/
Fermentation
/
Acides hydroxamiques
/
Métabolisme
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2015
Type:
Article
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