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Study on determination of entrapment efficiency of sinomenine liposomes / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 731-734, 2006.
Article Dans Chinois | WPRIM | ID: wpr-351771
ABSTRACT
<p><b>OBJECTIVE</b>To establish an HPLC method for the determination of entrapment efficiency of sinomenine liposomes.</p><p><b>METHOD</b>The liposomes and dissociated drugs were separated by sephadex filtration, mini-column centrifugation and dialysis. The methodology study and the optimization of determining condition were carried out at the same time.</p><p><b>RESULT</b>Sephadex filtration could effectively separate the sinomenine liposomes from dissociated sinomenine. The column recovery was 98.8%, the average entrapment efficiency of three tests was64.9%, RSD 2.67%.</p><p><b>CONCLUSION</b>The method was simple, exact, and had a good reappearance. It can be used to examine the entrapment efficiency of sinomenine liposomes.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Vecteurs de médicaments / Chimie / Dextrane / Technologie pharmaceutique / Systèmes de délivrance de médicaments / Sinomenium / Filtration / Liposomes / Méthodes / Morphinanes langue: Chinois Texte intégral: China Journal of Chinese Materia Medica Année: 2006 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Vecteurs de médicaments / Chimie / Dextrane / Technologie pharmaceutique / Systèmes de délivrance de médicaments / Sinomenium / Filtration / Liposomes / Méthodes / Morphinanes langue: Chinois Texte intégral: China Journal of Chinese Materia Medica Année: 2006 Type: Article