Research on gene expression of warm-hot drug treating cold syndrome / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 914-917, 2006.
Article
Dans Chinois
| WPRIM
| ID: wpr-351816
ABSTRACT
<p><b>OBJECTIVE</b>To study the therapeutic molecular mechanism of the warm-hot drugs treating cold syndrome.</p><p><b>METHOD</b>A brother and his sister with deficiency-cold syndrome were chosen and treated with appropriate Chinese formula consisted chiefly of warm-hot drugs for 45 days. Then microarray technique was applied for comparing the gene expression difference of sister who had significant effect, the data was dialed with multiple analysis method and the results were mined though gene function and pathway.</p><p><b>RESULT</b>276 differential genes were obtained, which were related to metabolism and 18 pathways.</p><p><b>CONCLUSION</b>Warm-hot drugs work on the gene expression of metabolism. It may be exerting the curative action by gene network and there is distinct difference between gene expression of curative effect and syndrome.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Syndrome
/
Médicaments issus de plantes chinoises
/
Déficit du Yang
/
Séquençage par oligonucléotides en batterie
/
Analyse de profil d'expression de gènes
/
Utilisations thérapeutiques
/
Traitement médicamenteux
/
Génétique
/
Maladies du rein
/
Médecine traditionnelle chinoise
Type d'étude:
Etude diagnostique
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2006
Type:
Article
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