Clinical observation of the long-term effects of rhEGF on deep partial-thickness burn wounds / 中华烧伤杂志
Chinese Journal of Burns
;
(6): 167-168, 2003.
Article
Dans Chinois
| WPRIM
| ID: wpr-352294
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the safety and long-term effect of recombinant human epithelial growth factor (rhEGF) on deep partial-thickness burn wounds.</p><p><b>METHODS</b>Thirty-seven burn patients were enrolled in this study and were observed by randomized, double-blinded and placebo-controlled protocol. An area of deep partial-thickness burn wounds from each patient was divided into control (C) and treatment (T) portions. The wound in C was treated with normal saline while that in T with rhEGF. The patients were followed-up for 1 and 4 years after wound healing. The healed wounds were evaluated by modified Vancouver scar scale in terms of scar index (SI).</p><p><b>RESULTS</b>1 year after wound healing, it was found that the SI in T group (7.19 +/- 1.67) was obviously lower than that in C group (8.92 +/- 1.78, P < 0.01). The SI in T group (6.12 +/- 1.54) was still evidently lower than that in C group (8.09 +/- 1.81, P < 0.01) four years after wound healing. There were no signs of development of tumor or cancer in all the tested burn wound areas.</p><p><b>CONCLUSION</b>External application of rhEGF might be beneficial to the healing quality of deep partial-thickness burn wound with less scar formation and better long-term effects, and it is safe.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Cicatrisation de plaie
/
Protéines recombinantes
/
Brûlures
/
Méthode en double aveugle
/
Études de suivi
/
Résultat thérapeutique
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Utilisations thérapeutiques
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Traitement médicamenteux
/
Facteur de croissance épidermique
Type d'étude:
Essai clinique contrôlé
/
Guide de pratique
/
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Burns
Année:
2003
Type:
Article
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