Comparative studies of vasodilating effects of angiotensin-(1-7) on the different vessels / 生理学报
Acta Physiologica Sinica
;
(6): 730-734, 2004.
Article
Dans Anglais
| WPRIM
| ID: wpr-352706
ABSTRACT
The purpose of this study was to compare the vasodilating effects of angiotensin-(1-7) [Ang-(1-7)] on the different vessels and to clarify its mechanisms by using relaxing responses of preconstricted vascular rings. The results showed (1) Ang-(1-7) dose-dependently induced vasorelaxation in all the vessels studied. However, there is apparent heterogeneity in the responsiveness of vessels from different origin. (2) The Ang-(1-7)-induced vasorelaxation was endothelium dependent and largely mediated by NO system. (3) The vasodilator action of Ang-(1-7) was not mediated by AT1 or AT2 receptor subtypes. It is suggested that the Ang-(1-7)-induced vasorelaxation is endothelium dependent by some other unclarified angiotensin receptor subtypes and is largely mediated by NO system.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Fragments peptidiques
/
Pharmacologie
/
Physiologie
/
Vasodilatateurs
/
Angiotensine-I
/
Endothélium vasculaire
/
Récepteur de type 1 à l'angiotensine-II
/
Métabolisme
/
Monoxyde d'azote
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Acta Physiologica Sinica
Année:
2004
Type:
Article
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