Meta-analysis of the association of Pro12Ala polymorphism of peroxisome proliferator activated receptor gamma gene with type 2 diabetes in Chinese Han population / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 593-599, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-352981
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the association of Pro12Ala polymorphism of peroxisome proliferator activated receptor gamma (PPARgamma) gene with type 2 diabetes (T2DM) in Chinese Han population.</p><p><b>METHODS</b>The present investigation was carried out using the keywords "PPARgamma", "pparg", "Pro12Ala", "type 2 diabetes", and "Chinese. The odds ratios (OR) for Ala12 used as the metric of choice were calculated in the dominant and additive model separately. The Meta-analysis was conducted by software STATA 11.0.</p><p><b>RESULTS</b>(1) We identified 22 studies, of which 17 studies involving 3927 type 2 diabetes cases and 3364 controls fell into the inclusion criteria. The analysis indicated no significant inter-study heterogeneity and publication bias. (2) The frequencies of the minor allele Ala12 in type 2 diabetes and control groups were 4.8% and 4.6% respectively. (3) The combined overall OR of dominant and additive model calculated by fix-effects meta-analysis for type 2 diabetes and the Pro12Ala polymorphism, were 0.95 (95% CI 0.80, 1.12) and 0.93 (95% CI 0.79, 1.09) respectively.</p><p><b>CONCLUSION</b>In this meta-analysis, the Pro12Ala gene variant (rs1801282) is not found to be associated with the susceptibility for type 2 diabetes in Chinese Han population.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polymorphisme génétique
/
Prédisposition génétique à une maladie
/
Asiatiques
/
Récepteur PPAR gamma
/
Diabète de type 2
/
Fréquence d'allèle
/
Génétique
Type d'étude:
Étude pronostique
/
Revues systématiques évaluées
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Acta Academiae Medicinae Sinicae
Année:
2011
Type:
Article
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