Therapeutic effect of cationic liposome-mediated interleukin-12 gene delivery on murine melanoma in vivo / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 73-76, 2005.
Article
Dans Zh
| WPRIM
| ID: wpr-353245
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the therapeutic effect of cationic liposome-mediated interleukin-12 gene delivery on established murine melanoma in vivo.</p><p><b>METHODS</b>The lipofectin encapsulated pCmIL-12 plasmid was given to C57BL/6 mice on the day 3,5,7,9 after inoculation of B16 melanoma cells. The tumor size, the survival time of mice and the NK cell activity were observed.</p><p><b>RESULTS</b>The pCmIL-12 plasmid coupled with cationic liposome inhibited the tumor growth and improved the survival of mice bearing established melanoma. The activity of NK cells was also enhanced after interleukin-12 gene delivery in vivo.</p><p><b>CONCLUSION</b>Cationic liposome-mediated interleukin-12 gene delivery has significantly therapeutic effects on mice melanoma in vivo.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Anatomopathologie
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Thérapeutique
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Mélanome expérimental
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ADN
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Cellules cancéreuses en culture
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Cellules tueuses naturelles
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Cations
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Interleukine-12
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Utilisations thérapeutiques
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Allergie et immunologie
Limites du sujet:
Animals
langue:
Zh
Texte intégral:
Journal of Zhejiang University. Medical sciences
Année:
2005
Type:
Article