Alcohol drinking and colorectal cancer: a population-based prospective cohort study / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To understand the incidence of colorectal cancer in population drinking or not and to validate the relationship between drinking and colorectal cancer.</p><p><b>METHODS</b>The data obtained from a questionnaire used in a population-based prospective screenings study in ten countries of Jiashan County was examined. A total of 64,102 men and women aged 30 y and older without history of cancer at baseline and a subcohort of 29,044 of them drinking past and current was conducted. Cox regression model was applied to estimate relative risk (RR).</p><p><b>RESULTS</b>After 10 years follow-up,107 colon cancer and 135 rectal cancer cases were identified. Among drinkers and abstainers, the incidence density of colorectal cancer was 36.18 per 100 thousand and 37.26 per 100 thousand, respectively and there wasn't statistical significance(Z=0.52, P>0.05); The crude RR (95%CI) for drinker compared with never drinkers was 0.97(0.75 approximately 1.25), and the multivariable-adjusted RR (95%CI) was 1.13(0.87 approximately 1.48). The research power of this study was 96.99%.</p><p><b>CONCLUSION</b>Alcohol drinking isn't one of the risk factors of colorectal cancer among Jiashan County population.</p>