Quantitative prediction of in vivo drug-drug interactions based on in vitro inhibition or/and induction data for CYP3A4 / 药学学报
Acta Pharmaceutica Sinica
;
(12): 952-959, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-353399
ABSTRACT
Inhibition or/and induction of CYP3A4 are the major mechanisms underlying the common clinical drug-drug interactions, which has been gained attention in new drug discovery and development as well as clinical practice. Quantitative prediction of drug-drug interactions at the early stage of drug development is advantageous for reducing the cost and duration of development and providing more information for the later clinical studies. The review summarizes the update progress on quantitative prediction of in vivo drug-drug interactions derived from models based on in vitro inhibition or/and induction for CYP3A4.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Préparations pharmaceutiques
/
Aire sous la courbe
/
Interactions médicamenteuses
/
Antienzymes
/
Cytochrome P-450 CYP3A
/
Inhibiteurs du cytochrome P-450 CYP3A
/
Intestins
/
Foie
/
Métabolisme
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2010
Type:
Article
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