Preparation, identification and inclusion actions of irisquinone hydroxypropyl-beta-cyclodextrin inclusion complex / 药学学报
Acta Pharmaceutica Sinica
;
(12): 369-372, 2005.
Article
Dans Chinois
| WPRIM
| ID: wpr-353493
ABSTRACT
<p><b>AIM</b>To perpare and identify irisquinone hydroxypropyl-beta-cyclodextrin inclusion complex (irisquinone-HP-beta-CD), as well as to study the inclusion mechanism and molecule stoichiometry between irisquinone and hydroxypropyl-beta-cyclodextrin.</p><p><b>METHODS</b>Irisquinone-HP-beta-CD was prepared by freeze-drying technique. The ratio of host and guest was also studied in inclusion process by mol gradient and continuing variational methods. At the same time, the inclusion complex was identified by X-ray diffraction (XRD) and differential scanning calorimetry (DSC).</p><p><b>RESULTS</b>It was demonstrated that the solubility of irisquinone was enhanced markedly by inclusion with HP-beta-CD when stoichiometry was 21 of host and guest at 25 degrees C, 35 degrees C and 45 degrees C.</p><p><b>CONCLUSION</b>The solubility and stability of irisquinone could be increased by preparing the inclusion complex with hydroxypropyl-beta-cyclodextrin.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Solubilité
/
Diffraction des rayons X
/
Calorimétrie différentielle à balayage
/
Chimie
/
Benzoquinones
/
Cyclodextrines bêta
/
Préparation de médicament
/
Stabilité de médicament
/
2-Hydroxypropyl-beta-cyclodextrin
/
Lyophilisation
Type d'étude:
Etude diagnostique
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2005
Type:
Article
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