Prognostic significance of EBMT score for chronic myeloid leukemia patients in allogeneic stem cell transplantation / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 75-78, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-353540
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the risk factors of allogeneic stem cell transplantation (allo-SCT) for chronic myeloid leukemia (CML) in an attempt to avoid transplant risks.</p><p><b>METHODS</b>A total of 121 CML patients received allo-SCT were analyzed retrospectively. The risk analysis was based on the EBMT score (gratwohl score) which included donor type, age of patients, disease status before transplantation, donor/recipient sex match and time interval between diagnosis to allo-SCT. Patients were divided into 3 risk groups based on their EBMT score low risk (score 0-2), intermediate risk (3-4) and high-risk (5).</p><p><b>RESULTS</b>The median follow-up duration was 37 (1 - 126) months. The estimated 5-year overall survival (5 y-OS), non-relapse mortality (5 y-NRM) and relapse rate (5 y-RR) were (56.8 ± 5.0)%, (35.6 ± 4.9)% and (12.9 ± 3.7)%, respectively. The 5y-OS, NRM and RR were (66.0 ± 6.1)%, (28.8 ± 6.0)% and (7.8 ± 3.3)% in the low risk group being significantly superior to both intermediate-risk \[(47.2 ± 8.7)%, (43.6 ± 8.5)% and (18.7 ± 8.1)%\] and high-risk group \[(16.8 ± 15.2)%, (66.7 ± 25.5)% and (50.0 ± 25.0)%\] (P = 0.0015, 0.045 and 0.0053 for OS, NRM and RR respectively).</p><p><b>CONCLUSION</b>The EBMT risk score can effectively predict the overall outcome, relapse and transplant-related mortality of allo-SCT for CML patients.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pronostic
/
Chirurgie générale
/
Donneurs de tissus
/
Transplantation homologue
/
Leucémie myéloïde chronique BCR-ABL positive
/
Études rétrospectives
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Facteurs de risque
/
Études de suivi
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Transplantation de cellules souches hématopoïétiques
/
Diagnostic
Type d'étude:
Etude diagnostique
/
Etude d'étiologie
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Adulte
/
Enfant
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Hematology
Année:
2011
Type:
Article
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