High-dose chemotherapy/autologous stem cell transplantation for nasopharyngeal T cell lymphoma / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 515-518, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-353600
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the role of high-dose chemotherapy (HCT)/autologous stem cell transplantation (ASCT) for nasopharyngeal T cell lymphomas.</p><p><b>METHODS</b>A retrospective review of 51 patients who underwent HCT/ASCT between January 1995 and January 2007.</p><p><b>RESULTS</b>Of the 51 patients who underwent ASCT, no treatment-related death was seen; sixteen patients relapsed after transplant, two patients are still alive through salvage chemotherapy 91 months and 56 months after relapse, the other fourteen patients died in tumor progression. 1-year, 3-year and 5-year overall survival (OS) rates were 98.0%, 84.0% and 72.0%, respectively. 1-year, 3-year and 5-year progression-free survival (PFS) rates were 90.2%, 78.4%and 66.7%, respectively. Univariate analysis showed that clinical stage, B symptom and IPI were prognostic factors for patients with nasopharyngeal T cell lymphomas, the P value being 0.041, 0.036 and 0.031, respectively.</p><p><b>CONCLUSION</b>High-dose therapy/autologous stem cell transplantation can improve cure rate and prolong survival time significantly in patients with nasopharyngeal T cell lymphomas.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pronostic
/
Transplantation autologue
/
Protocoles de polychimiothérapie antinéoplasique
/
Études rétrospectives
/
Lymphome T
/
Résultat thérapeutique
/
Utilisations thérapeutiques
/
Récidive tumorale locale
Type d'étude:
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Hematology
Année:
2010
Type:
Article
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