Association of chronic obstructive pulmonary disease with coronary artery disease / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 3205-3208, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-354508
ABSTRACT
<p><b>BACKGROUND</b>The relationship between chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD) remains largely unknown. This study aimed to explore the association of COPD with CAD, especially with multi-vessel disease (VD).</p><p><b>METHODS</b>The data of 354 patients who underwent multi-detector computed tomography (MDCT) for suspected CAD were analyzed. Luminal narrowing was defined as at least one lesion 50% or greater stenosis. The analysis of serum biochemistry profile and spirometry were performed on all eligible patients, and the diagnosis of COPD was defined as the criteria of Global Initiative for Chronic Obstructive Lung Disease.</p><p><b>RESULTS</b>Patients with CAD had a significantly higher complication of COPD than those without CAD (11.8% vs. 3.7%, P < 0.001). Comparing with patients without COPD, those with COPD were more likely to have multi-VD, proportion of smoking and high C-reactive protein (CRP) (P < 0.001). Multivariate Logistic regression analysis revealed that the multi-VD was significantly correlated with COPD (P=0.012) and CRP (P=0.015).</p><p><b>CONCLUSIONS</b>There was a high complication of COPD in patients with CAD, and COPD may be a critical risk factor for CAD, especially for multi-VD. CAD and COPD were closely associated and the interplay of systemic inflammation might in part explain the relationship between them.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Maladie des artères coronaires
/
Imagerie diagnostique
/
Radiographie
/
Facteurs de risque
/
Broncho-pneumopathie chronique obstructive
/
Métabolisme
Type d'étude:
Etude diagnostique
/
Etude d'étiologie
/
Facteurs de risque
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Chinese Medical Journal
Année:
2013
Type:
Article
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