A new cytotoxic metabolite from a deep sea derived fungus, Phialocephala sp / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1275-1278, 2010.
Article
Dans Anglais
| WPRIM
| ID: wpr-354527
ABSTRACT
A new sesquiterpene hydroquinone (1) was isolated from a deep sea sediment derived fungus, Phialocephala sp.. Its structure and stereochemistry were established on the basis of spectroscopic data and optical rotation. This compound was tested for cytotoxicity against P388 (murine leukemia cell) and K562 (human leukemia cell) cell lines, and displayed strong cytotoxic effects with IC50 value of 0.16 and 0.05 micromol x L(-1), separately.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pharmacologie
/
Ascomycota
/
Structure moléculaire
/
Leucémie P388
/
Survie cellulaire
/
Chimie
/
Cellules K562
/
Concentration inhibitrice 50
/
Lignée cellulaire tumorale
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2010
Type:
Article
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