Design and synthesis of nitrogen-containing benzoheterocyclic derivatives and their antipsychotic activities / 药学学报
Acta Pharmaceutica Sinica
;
(12): 994-1001, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-354606
ABSTRACT
A series of nitrogen-containing benzoheterocyclic derivatives were synthesized and tested for their antipsychotic activities. Their structures were confirmed by 1H NMR and HR-MS. Preliminary in vitro pharmacological trials showed that most of the target compounds have high affinity with D2 and 5-HT(2A) receptors. Among the tested compounds, 20 exhibited the highest affinity and D2 partial agonist activity. In vivo studies showed 20 has potent antipsychotic activities on apomorphine mice model, which is a chance to find a better precursor of D2 partial agonist for further optimization.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Relation structure-activité
/
Neuroleptiques
/
Conception de médicament
/
Récepteur D2 de la dopamine
/
Agonistes de la dopamine
/
Isoquinoléines
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2009
Type:
Article
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