Therapeutic effect of adenovirus-mediated apoptin gene transfer combined with ADM and CDDP on hepatocellular carcinoma in mice / 南方医科大学学报
Journal of Southern Medical University
;
(12): 538-540, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-355079
ABSTRACT
<p><b>OBJECTIVE</b>To study the therapeutic effect adenovirus-mediated apoptin gene transfer combined with ADM and CDDP on hepatocellular carcinoma in mice.</p><p><b>METHODS</b>In c57BL/ 6 mice bearing hepatocellular carcinoma, the changes of tumor volume, histomorphology, tumor inhibition rate and the side effects were observed after intratumoral injection of adenovirus containing apoptin gene and ADM and CDDP.</p><p><b>RESULTS</b>Seven days after the treatment, the mean volume of the tumor in the mice receiving intratumoral apoptin-containing adenovirus injection combined with ADM and CDDP reduced significantly as compared with that in mice treated with adenovirus vehicle and control group. The tumor inhibition rate in the combined treatment group was 90.13%, significantly higher than that in the control group. No adverse effect of the treat was observed in the course of the experiment.</p><p><b>CONCLUSION</b>The adenovirus vectors containing apoptin gene combined with ADM and CDDP may serve a safe treatment of hepatocellular carcinoma.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Thérapeutique
/
Thérapie génétique
/
Protocoles de polychimiothérapie antinéoplasique
/
Doxorubicine
/
Répartition aléatoire
/
Adenoviridae
/
Cisplatine
/
Techniques de transfert de gènes
/
Association thérapeutique
/
Protéines de capside
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2010
Type:
Article
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