Bilateral Metachronous Breast Cancer in Neurofibromatosis Type 1
Journal of the Korean Surgical Society
;
: 388-391, 2009.
Article
Dans Coréen
| WPRIM
| ID: wpr-35508
ABSTRACT
Neurofibromatosis type 1 (NF1) is an autosomal dominant disease, characterized by cafe-au-lait spot, axillary and inguinal freckle, peripheral neurofibroma and pigmented iris hamartoma. The various cancer incidences are increased in the NF1. But NF1 with breast cancer is rare. In this report we present a case of a 46-year-old NF1 female with a bilateral metachronous breast cancer. The patient has no BRCA2 mutation, but there are two unclassified variants in the exon 11 of BRCA1. The possibility of LOH of BRCA1 gene in the cancer tissue cannot be excluded.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Région mammaire
/
Tumeurs du sein
/
Iris
/
Exons
/
Incidence
/
Neurofibromatose de type 1
/
Neurofibromatoses
/
Taches café-au-lait
/
Gène BRCA1
/
Hamartomes
Type d'étude:
Etude d'incidence
/
Étude pronostique
Limites du sujet:
Femelle
/
Humains
langue:
Coréen
Texte intégral:
Journal of the Korean Surgical Society
Année:
2009
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS