Characteristics of polymorphism of 129th amino acid in PRNP among Han and Uighur Chinese / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 105-108, 2002.
Article
Dans Chinois
| WPRIM
| ID: wpr-355117
ABSTRACT
<p><b>BACKGROUND</b>An amino acid polymorphism for Met to Val has been identified at PrP codon 129 from different human races. In this study,the characteristics of polymorphism of PRNP 129th amino acid in Han and Uighur Chinese have been investigated.</p><p><b>METHODS</b>Human DNAs were extracted from peripheral lymphocytes and PrP gene fragments were amplified with a specific PCR protocol. The distribution of 129th amino acid in PRNP was determined by a PCR-RFLP and the results were analyzed with software SAS for Windows 6.12.</p><p><b>RESULTS</b>The frequencies of the allele 129 Met and 129 Val were 97.0% and 3.0% in Han Chinese, whereas 91.4% and 8.6% in Uighur Chinese. The frequency of 129 M/M phenotypes in Han Chinese was significantly higher than that in Uighur Chinese (P=0.0490). Comparing the phenotype distributions of codon 129 of Han Chinese with that of Japanese and Caucasian, there was significant difference with Caucasian (P=0.0005),but there was no difference with Japanese (P=0.5040).</p><p><b>CONCLUSIONS</b>The polymorphism of 129th amino acid in PRNP of Han Chinese is similar to Japanese, but different from Uighur Chinese.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polymorphisme génétique
/
Prions
/
Codon
/
Chine
/
Maladies à prions
/
Asiatiques
/
/
Fréquence d'allèle
/
Génétique
/
Génotype
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
Pays comme sujet:
Asie
langue:
Chinois
Texte intégral:
Chinese Journal of Experimental and Clinical Virology
Année:
2002
Type:
Article
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