Ultrastructure and crystallin mutant molecular modeling of hereditary coralliform cataract / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 243-247, 2005.
Article
Dans Chinois
| WPRIM
| ID: wpr-355232
ABSTRACT
<p><b>OBJECTIVE</b>To observe the correlation of gammaD-crystallin P23T mutant with lens ultrastructure of the hereditary coralliform cataract.</p><p><b>METHODS</b>Complete ophthalmologic examinations were performed before lens extraction and lens samples were studied by transmission and scanning electric microscope respectively. Protein molecular modeling was performed using SWISS-MODEL(version 2.0).</p><p><b>RESULTS</b>Protein structure modeling demonstrated that the mutant caused a decrease in molecular final total energy and changes in the surface structure of gammaD-crystallin. Ultrastructure study revealed crystals deposited in lens, extensive granules dispersed in uncommon oval structure and the disorganization of lens epithelial cells.</p><p><b>CONCLUSION</b>It is possible that the gammaD-crystallin P23T mutant is associated with abnormal crystals in lens and disorganization of lens epithelial cells.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pedigree
/
Phénotype
/
Cataracte
/
Mutation ponctuelle
/
Cristallines-gamma
/
Génétique
/
Cristallin
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Zhejiang University. Medical sciences
Année:
2005
Type:
Article
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