Upregulated PGC-NRF-mtTFA expressions contributed to the development of atherosclerosis in rabbits fed with a high fat diet / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 646-650, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-355921
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between PPAR coactivator 1 (PGC-1), nuclear respiratory factor (NRF), mitochondrial transcription factor A (mtTFA) expressions of vascular smooth muscle cells (VSMC) and development of atherosclerosis in a rabbit model.</p><p><b>METHODS</b>Atherosclerotic model was established by feeding the rabbits with high-fat diet for 4, 8 and 12 weeks (n = 10 each). Another 8 rabbits fed with normal diet served as normal controls. Intima-media ratio, mRNA and protein expressions of PGC-1, NRF, mtTFA and SMemb, a marker for synthetic VSMC, were detected on aorta specimens.</p><p><b>RESULTS</b>With the blood lipid increased, the intima-media ratio rose from (0.031 +/- 0.010) microm up to (0.814 +/- 0.258) microm during 12 weeks. Increasing SMemb means that synthetic VSMC grew more and more. The expressions of PGC-1 became significant after 4 weeks (P < 0.01), while that of NRF-1 and mtTFA rose significantly after 8 weeks (P < 0.01).</p><p><b>CONCLUSIONS</b>The PGC-NRF-mtTFA pathway might play a critical role in VSMC proliferation and development of atherosclerosis.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Facteurs de transcription
/
Sang
/
Transactivateurs
/
Protéines mitochondriales
/
Modèles animaux de maladie humaine
/
Protéines de liaison à l'ADN
/
Athérosclérose
/
Facteur nucléaire-1 respiratoire
/
Lipides
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Chinese Journal of Cardiology
Année:
2008
Type:
Article
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