Impact on absorption of berberine and palmatine in different compatibilities of Wuji pill / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the impact on absorption of berberine and palmatine in different compatibilities of Wuji pill by the perfused rat intestine-liver preparation.</p><p><b>METHOD</b>Use L9 (3(4)) orthogonal design table, establish the perfused rat intestine-liver preparation, the twelve Wuji pill compatibilities duodenal administrated, collect the perfusate at different times points for LC-MS detection, calculate the absorbed score, Ka.</p><p><b>RESULT</b>Evodiae Fructus and the absorption score, Ka of berberine and palmatine are inverse correlated. The most superior portion which promote the absorption is Coptidis Rhizoma-Evodiae Fructus-Paeoniae Radix Alba 3:1:3.</p><p><b>CONCLUSION</b>Evodiae Fructus suppressed the absorption of berberine and palmatine. With the different portion the absorption also have big different.</p>