Research progress on chemokine receptor 5-targeted therapy for HIV-1 / 病毒学报
Chinese Journal of Virology
;
(6): 79-83, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-356634
ABSTRACT
Along with the spread of human immunodeficiency virus 1 (HIV-1) infection in the world and the emergence of drug-resistant viral strains, it is urgent to seek the novel potent therapies. Chemokine receptor 5 (CCR5) is one of the main coreceptors involved in the entry of HIV-1 into target cells. Nowadays, a number of CCR5 antagonists have been developed and some of them have progressed to clinical trials or been approved. Research progress has also been made in the CCR5-targeted gene therapy. This review summarizes the recent research progress on the CCR5-targeted drug and gene therapy.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Infections à VIH
/
VIH-1 (Virus de l'Immunodéficience Humaine de type 1)
/
Récepteurs CCR5
/
Traitement médicamenteux
/
Thérapie moléculaire ciblée
/
Antagonistes des récepteurs CCR5
/
Génétique
/
Métabolisme
/
Méthodes
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Virology
Année:
2014
Type:
Article
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