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Protective effect of Isodon lophanthoides var. gerardianus on acute hepatic injury induced by carbon tetrachloride in rats / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 574-577, 2006.
Article Dans Chinois | WPRIM | ID: wpr-356765
ABSTRACT
<p><b>OBJECTIVE</b>To study the protective effects of Isodon lophanthoides var. gerardianus (ILVG) aqueous extract on the acute hepatic injury induced by carbon tetrachloride (CCl4) in rats.</p><p><b>METHOD</b>Sixty rats were allocated into control group, model group, low, middle and high dosage group and Bifendate group randomly. At the test group, rats received either ILVG aqueous extract (15, 7.5, 3.75 g x kg(-1)) or Bifendate (45 mg x kg(-1)) by gastric perfusion daily for 10 consecutive days. In 1st, 4th, 7th and 10th days, 10% CCl4 (2 mL x kg(-1)) was given to rats by intraperitoneal (ip) injection. The rats were killed 24 h after the last adminiction with drug, the levels of ALT, AST, ALP and total bilirubin in serum were analyzed, the body weight, liver weight, spleen weight and thymus weight of each rat were measured, and the hepatic tissue pathology was observed.</p><p><b>RESULT</b>ILVG could decrease the ALT, AST, ALP and T-Bil in serum, restrain the enlargement of liver and the shrinkage of thymus, and reduce the necrosis in pathological observation.</p><p><b>CONCLUSION</b>ILVG aqueous extract possesses the effects of protecting on the acute hepatic injury induced by CCl4 in rats.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Anatomopathologie / Pharmacologie / Plantes médicinales / Aspartate aminotransferases / Bilirubine / Sang / Médicaments issus de plantes chinoises / Intoxication au tétrachlorure de carbone / Répartition aléatoire / Chimie Limites du sujet: Animaux langue: Chinois Texte intégral: China Journal of Chinese Materia Medica Année: 2006 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Anatomopathologie / Pharmacologie / Plantes médicinales / Aspartate aminotransferases / Bilirubine / Sang / Médicaments issus de plantes chinoises / Intoxication au tétrachlorure de carbone / Répartition aléatoire / Chimie Limites du sujet: Animaux langue: Chinois Texte intégral: China Journal of Chinese Materia Medica Année: 2006 Type: Article