A randomized, controlled clinical trial on meropenem versus imipenem/cilastatin for the treatment of bacterial infections / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1849-1854, 2002.
Article
Dans Anglais
| WPRIM
| ID: wpr-356894
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and safety of meropenem in Chinese patients, we conducted a study for the treatment of patients with lower respiratory tract infections, urinary tract infections and other infections.</p><p><b>METHODS</b>A total of 182 hospitalized patients were enrolled in the study. 90 patients received 500 mg meropenem every 12 hours (or 1 g every 12 hours if necessary) and 92 patients received imipenem/cilastatin 500 mg/500 mg every 12 hours (or 1 g every 12 hours if necessary) by intravenous infusion. The duration of treatment was 7 - 14 days for both groups.</p><p><b>RESULTS</b>Seventy of 90 cases receiving meropenem and 70 of 92 cases receiving imipenem/cilastatin were assessable for clinical efficacy. The overall efficacy rates were 90% for the meropenem group and 87% for the imipenem/cilastatin group, and the bacterial eradication rates were 86% in both groups. 93 (76%) of 123 strains isolated from patients produced beta-lactamases. Adverse drug reactions were evaluated in 72 cases in the meropenem group and 70 cases in the imipenem/cilastatin group. The adverse drug reaction rates were 9.7% and 8.6%, respectively. The results showed that there were no statistical differences between these two groups (P > 0.05).</p><p><b>CONCLUSION</b>Meropenem is effective and safe for the treatment of bacterial infections caused mainly by beta-lactamase-producing strains.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Aspartate aminotransferases
/
Infections de l'appareil respiratoire
/
Infections urinaires
/
Sang
/
Cilastatine
/
Thiénamycine
/
Imipénem
/
Utilisations thérapeutiques
/
Alanine transaminase
/
Traitement médicamenteux
Type d'étude:
Essai clinique contrôlé
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Chinese Medical Journal
Année:
2002
Type:
Article
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