Differences in Clinical Manifestations and Outcomes between Adult and Child Patients with Henoch-Schonlein Purpura
Journal of Korean Medical Science
;
: 198-203, 2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-35690
ABSTRACT
We aimed to investigate differences in clinical manifestations and outcomes between adult and child patients with Henoch-Schonlein purpura (HSP), and to analyze the factors associated with poor prognosis for HSP nephritis. This retrospective 10-yr study enrolled 160 patients with HSP who visited Severance Hospital. Purpura was mostly detected in lower extremities, but purpura in upper extremities was more frequently observed in adults than children (41.7% vs 19.3%). Children had a greater frequency of arthralgia (55.4% vs 27.1%), while adults had a greater frequency of diarrhea (20% vs 1.6%). Anemia, elevated C-reactive protein, and level of IgA were more frequently observed in adults (25% vs 7.1%, 65.6% vs 38.4%, 26.3% vs 3.5%). Renal involvement in adults was more severe than in children (79.2% vs 30.4%). Chronic renal failure showed a significant difference in outcomes of HSP between adults (10.4%) and children (1.8%) after a follow up period of an average of 27 months. Furthermore, renal insufficiency at diagnosis was significantly related to the progression to chronic renal failure. Our results showed several differences in the clinical features of HSP between adults and children. Adults with HSP had a higher frequency of renal insufficiency and worse renal outcomes than children. Renal insufficiency at diagnosis might be of predictive value for the progression to chronic renal failure in HSP patients.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pronostic
/
/
Protéine C-réactive
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Immunoglobuline A
/
Odds ratio
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Études rétrospectives
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Études de suivi
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Arthralgie
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Diarrhée
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Insuffisance rénale
Type d'étude:
Etude d'étiologie
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Étude observationnelle
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Étude pronostique
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Facteurs de risque
Limites du sujet:
Adulte
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Adulte très âgé
/
Aged80
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Enfant
/
Enfant d'âge préscolaire
/
Femelle
/
Humains
/
Bébé
langue:
Anglais
Texte intégral:
Journal of Korean Medical Science
Année:
2014
Type:
Article
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