Pro-apoptosis and selective anticancer activities of prostate apoptosis response protein 4: research progress and prospects / 南方医科大学学报
Journal of Southern Medical University
;
(12): 128-132, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-356970
ABSTRACT
As a pro-apoptotic factor, prostate apoptosis response protein 4 (par-4) was first found in the male hormone-dependent prostate cells (AT-3). Endogenous Par-4 sensitizes cancer cells to apoptotic stimuli, but exogenous Par-4 selectively induces apoptosis in cancer cells, and these activities depends on the structure of its core domain SAC. Par-4 and SAC can specifically induce apoptosis of cancer cells but not of normal cells, and are therefore potential anti-cancer drugs. In this review we summarize the discovery, structure, and function of par-4, and its intracellular signaling pathways, then discuss the application prospects of Par-4 and SAC in the clinical treatment of cancer and the problems in its research and clinical applications.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Apoptose
/
Protéines suppresseurs de tumeurs
/
Protéines régulatrices de l'apoptose
/
Métabolisme
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2014
Type:
Article
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