Influence of flow shear stress on apoptosis of arterial endothelium in vivo / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 392-394, 2002.
Article
Dans Chinois
| WPRIM
| ID: wpr-357019
ABSTRACT
To explore the changes of wall shear stress(WSS) effect on arterial endothelial cell(EC) apoptosis after reducing arterial blood flow. The reducing flow model was established in 60 rabbits. Endothelial stretched preparations were made at 8 different time intervals from 0 to 30 days. The apoptosis rate of arterial endothelial cells (AEC) was measured with TdT-mediated dUTP-biotin nick end labeling(TUNEL) method. The results showed that the apoptosis rate of AEC was significantly higher from 1 day to 7 days after decreasing WSS than that of control, which peaked on day 3. While with progressively increasing in WSS, the apoptosis rate restored to the level of control from 14 days to 30 days. These suggest that the apoptosis state of AEC might be markedly influenced by the changes of WSS. The persist decreasing of WSS may be the important factor which induces the cell apoptosis.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Physiologie
/
Artères
/
Débit sanguin régional
/
Endothélium vasculaire
/
Apoptose
/
Biologie cellulaire
/
Résistance au cisaillement
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Journal of Biomedical Engineering
Année:
2002
Type:
Article
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